Metabolically Active Folate* Superior Bioavailability Methylfolate is the biologically active, naturally occurring form of folate that is used for fundamental body functions like normal cell division and the synthesis of neurotransmitters and DNA.* Unlike regular folic acid, Methylfolate has been shown to penetrate the blood-brain barrier, where it helps to support neurological health.* Quatrefolic� is a patented form of Methylfolate that has demonstrated bioavailability superior to that of folate from dietary sources. Quatrefolic� is a registered trademark of Gnosis S.p.A. and protected by U.S. Patent 7,947,662.